Insulin-Like Growth Factor-I, IGF-Binding Protein-3, and Mammographic Breast Density
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density.
Some studies have suggested that insulin-like growth factor (IGF) pathway is related to premenopausal breast density, one of the strongest known breast cancer risk factors. This study was designed specifically to test the hypothesis that higher levels of IGF-I and lower levels of IGF-binding protein (IGFBP)-3 are associated with high mammographic breast density among premenopausal but not among...
متن کاملPlasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density.
Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development of breast tissue and possibly in the etiology of breast cancer. Breast density is one of the strongest predictors of breast cancer. In a cross-sectional analysis within the Nurses' Health Study, we compared the associations of plasma levels of endogenous IGF-I and IG...
متن کاملInsulin-like growth factor-I and mammographic breast density.
To the Editor: Diorio and colleagues recently (1) reported a direct association of the percentage of mammographic density with plasma insulin-like growth factor-I (IGF-I) in a large cross-sectional study. As in previous studies (2, 3), this association was stronger in premenopausal women, and findings were interpreted as support for the hypothesis that elevated plasma IGF-I increases breast can...
متن کاملInsulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer.
Epidemiological evidence supports a role for the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the induction and progression of various cancers. Estrogen, which plays a role in the etiology of breast cancer, both regulates and is influenced by the IGF family. Risk of breast cancer associated with serum levels of IGF-I and/or IGFBPs may therefore depend upon menopausa...
متن کاملInsulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on.
Insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, are multi-functional regulatory peptides of cell growth and survival, attributes important for tumourigenesis. Following seminal work published in 1998, it has been hypothesised that circulating concentrations of these growth factors may be associated with cancer risk. Systematic reviews have reported that high normal ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2005
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-04-0706